![]() ![]() ![]() “These mice have abnormal vocalizations, and in the striatum there are many cellular abnormalities,” says Ann Graybiel, an MIT Institute Professor, a member of MIT’s McGovern Institute for Brain Research, and an author of the paper. Those malfunctions arise because Foxp2 mutations prevent the proper assembly of motor proteins, which move molecules within cells, the researchers found. Mice with these mutations also showed impairments in their ability to produce the high-frequency sounds that they use to communicate with other mice. In a study of mice, the researchers found that mutations in Foxp2 disrupt the formation of dendrites and neuronal synapses in the brain’s striatum, which plays important roles in the control of movement. A new study from MIT and National Yang Ming Chiao Tung University sheds light on how this gene controls the ability to produce speech. Mutations of a gene called Foxp2 have been linked to a type of speech disorder called apraxia that makes it difficult to produce sequences of sound. Sharp Lecture in Neural Circuitsįaulty versions of the Foxp2 gene disrupt neurons’ ability to form synapses in brain regions involved in speech, a new study shows. Poitras Center for Psychiatric Disorders Research.Principal Research Scientists Open Principal Research Scientists. ![]()
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